血浆TC/HDL-C和LDL-C/HDL-C比值与冠心病严重程度的相关性分析

Analysis on the relativity of the plasma TC/HDL-C,LDL-C/HDL-C with the severity of coronary heart disease

目的探讨血浆TC/HDL-C、LDL-C/HDL-C比值预测冠心病严重程度的价值。方法选择笔者所在医院2013年5月—2015年5月因胸痛、心前区不适行冠状动脉造影术的患者250例。按照诊断结果分为非冠心病组71例、单支病变组93例、多支病变组86例,分析三组血脂差异及冠状动脉不同病变程度(单支、多支)与血脂变化的相关性。结果非冠心病组TC、TG、LDL-C等指标均明显低于冠心病患者(单支和多支病变),组间比较,差异有高度统计学意义(P<0.01);而HDL-C指标对比结果,非冠心病组均明显高于冠心病患者(P<0.01);单支病变组TC、TG、LDL-C等指标与多支病变组比较,P>0.05;但单支病变组HDL-C指标明显高于多支病变组,组间比较,P<0.05;HDL-C与冠状动脉病变支数呈负相关,P<0.01;TC、TG、LDL-C指标与冠状动脉病变支数无明显相关性,P>0.05;非冠心病组TC/HDL-C、LDL-C/HDL-C、TG/HDL-C比值明显低于单支病变组和多支病变组,组间比较,差异有统计学意义(P<0.01);单支病变组TC/HDL-C、LDL-C/HDL-C、TG/HDL-C比值明显低于多支病变组,组间比较,差异有统计学意义(P<0.01);TC/HDL-C、LDL-C/HDL-C与冠状动脉病变支数呈正相关(P<0.01);TG/HDL-C与冠状动脉病变支数无明显相关性。结论 TC/HDL-C、LDL-C/HDL-C比值可作为临床预测心血管严重程度的可靠指标。

Objective To investigate the value of plasma TC/HDL-C,LDL-C/HDL-C in predicting the severity of coronary heart disease. Methods From May 2013 to May 2015 in author＇s hospital,250 patients with chest pain and discomfort in the anterior region of the heart were selected in this study. According to the diagnosis resuhs,71 cases were divided into non-coronary heart disease group （93 cases）,single vessel disease group（three cases） and multiple vessel disease group（86 cases）,the difference of blood lipids and the correlation between different levels of coronary artery disease （single branch,multiple branch） and blood lipid were analyzed. Results Non CHD group TC,TG,LDL-C,and other indicators were significantly lower than those of patients with coronary heart disease （single and multivessel lesion）,comparison between the groups has significant difference,P〈 0.01;HDL-C index comparison results,non CHD group were significantly higher than those in patients with coronary heart disease,comparison between the groups was statistically significant in the difference （P〈0.01）; compared with the multi branch lesion in single vessel disease group TC and TG,LDL-C and other indicators had no significant difference ,P〉0.05 ;but the single vessel group＇s HDL-C index was significantly higher than that of multivessel disease group,comparison between the groups has significant difference,P〈0.05;while the ratio of TC/ HDL-C muhivessel disease was significantly lower than that of group,comparison between the groups,P〈0.01 ;TC/ HDL-C and coronary lesions count was positively correlated,P〈0.01;HDL-C was negatively correlated with the number of diseased coronary artery,P〈0.01;in TC,TG,LDL-C no significant correlation was found between the number of indicators and coronary artery disease,P〉0.05, in non CHD group TC/HDL-C,LDL-C/HDL-C,TG/HDL- C ratio was significantly lower than that of the single branch lesion group and multi branch lesion group,compared between the groups showed statistical significance,P〈0.01;in single branch lesion group TC/HDL-C,LDL-C/HDL-C, TG/HDL-C ratio was significantly lower than that of in multi branch lesion group with statistical significance,P〈 0.01 ;TC/HDL-C,LDL-C/HDL-C and^the severity of coronary artery lesion counts were positively correlated,P〈0.01; TG/HDL-C and the number of diseased coronary artery had no obvious correlation. Conclusion The TC/HDL-C, LDL-C/HDL-C ratio can be used as a reliable index for predicting the severity of cardiovascular disease.