第二只眼行白内障手术时疼痛增加的炎性细胞因子研究进展

Inflammatory cytokines research progress on the increase of pain during the second-eye cat aract surgery

在白内障领域,有这样一个普遍的现象:多数患者都抱怨第二只眼行白内障手术时比第一只眼要疼一些。对该现象的新近研究发现,第一只眼睛行白内障手术后,在第二只眼房水中存在高表达的一种细胞因子即单核细胞趋化因子-1。从分子水平分析第二只眼行白内障手术时疼痛增加的机制,是现今研究的热点,单核细胞趋化因子-1(monocyte chemoattractant protein,MCP-1),被认为是疼痛家族的一个新成员,是一个重要的导致疼痛发生的因子,与其特异性受体CCR2结合发挥其生物学活性。本文就第二只眼行白内障手术时疼痛增加的炎性细胞因子研究进展做一综述。

In the field of cataract,there is such a widespread phenomenon：the majority of patients have complained thatthe second- eye phacoemulsification is often more painful than the first-eye surgery.Recent studies on this phenomenon have found that after cataract surgery in the first eye,in the second-eye aqueous humor there is a high expression of cytokines which is monocyte chemotactic factor-1.It is the focus of the present study to analyze the mechanism of the increase of pain in the second eye with cataract surgery from the molecular level.Monocyte chemotactic factor- 1（monocyte chemoattractant protein,MCP-1） which is considered to be a new member of the family of pain,is an important factor resulting in pain,and its specific receptor CCR2 binding exerts its biological activity.This is a review of the inflammatory cytokine research progress on the increase of pain during the second-eye cataract surgery.