胃泌素释放肽前体对小细胞肺癌诊断的临床意义

The diagnostic value of ProGRP for small cell lung cancer

目的探讨胃泌素释放肽前体(ProGRP)在小细胞肺癌(SCLC)诊断中的意义。方法收集2016年4月15日至7月19日明确诊断的SCLC 23例,非小细胞肺癌(NSCLC)40例,良性肺疾病患者(BPD)43例及健康对照组40例,检测患者血清中的ProGRP水平,评估其对SCLC的临床价值。结果 SCLC组中的ProGRP水平显著高于NSCLC组、BPD组和健康对照组,广泛期SCLC组的ProGRP水平高于局限期SCLC组,差异均有统计学意义(P<0.05)。各组内ProGRP阳性率在性别和年龄间的差异无统计学意义(P>0.05)。ProGRP诊断SCLC的临界值为65.66ng/L,敏感度和特异性分别为90.9%和89.9%。结论 ProGRP是1种敏感且特异的SCLC诊断指标,ProGRP水平的高低还可用于SCLC的病情监测。

Objective To explore the clinical significance of serum ProGRP in diagnosis of SCLC.Methods Serum ProGRP were detected in twenty-three SCLC patients,forty NSCLC patients and forty-three patients with benign pulmonary disease whose were definite diagnosis collected from April 15,2016 to July 19,2016,and a contemporary cohort of 40 healthy controls were while recruited.Results The levels of ProGRP in SCLC group were significantly higher than those in NSCLC group,benign pulmonary disease group and healthy control group（P〈0.05）.The levels of ProGRP in extensive disease group were significantly higher than those in 1imited disease group（P〈0.05）.There was no significant difference in the positive rates of ProGRP between the sex group and age group（P〉0.05）.The boundary value of diagnosis of SCLC through ProGRP identified through ROC curve was65.66ng/L.The sensitivity and specificity of the ProGRP for the diagnosis of SCLC were respectively 90.9% and 89.9%.Conclusion Serum ProGRP can be use as a sensitive and specific index for diagnosis of SCLC,and the level of ProGRP can also be used for the clinical staging of SCLC.