25(OH)D在重症肺炎患儿中的水平及相关性研究

Study of 25-hydroxy vitamin D level and correlation in children with severe pneumonia

目的探讨重症肺炎患儿25羟基维生素D[25(OH)D]水平以及与C反应蛋白、降钙素原的相关性。方法采用酶联免疫吸附法分别测定86例重症肺炎、81例轻症肺炎患儿入院时以及85例健康对照组儿童的25(OH)D水平,并进行比较;同时测定重症肺炎患儿C反应蛋白、降钙素原水平并与25(OH)D水平进行相关性分析。结果重症肺炎组、轻症肺炎组患儿与健康对照组儿童血清25(OH)D水平分别为(62.03±17.94)、(68.90±15.22)与(82.21±17.89)μmol/L,差异有统计学意义(P<0.05,α=0.05),且重症肺炎组25(OH)D缺乏率明显高于轻症肺炎组患儿和健康对照组儿童(P<0.05,α=0.05);重症肺炎患儿25(OH)D水平与C反应蛋白、降钙素原水平没有明显相关性(P>0.05,α=0.05)。结论重症肺炎患儿25(OH)D水平明显降低,可能与疾病发生发展有关联。

Objective To investigate the level of 25-hydroxyvitamin D[25（OH）D]and relationship to C-reactive protein（CRP）and procalcitonin（PCT）in children with severe pneumonia.Methods Serum 25（OH）D levels of 86 cases of children with severe pneumonia,81 cases of children with mild pneumonia and 85 cases of children in healthy control group on admission were determined by ELISA respectively and compared.At the same time,CRP and PCT were tested and the correlation to 25（OH）D in children with severe pneumonia was analyzed.Results There are statistical differences among three groups（P〈0.05,α=0.05）.The mean values of serum 25（OH）D were（62.03±17.94）,（68.90±15.22）and（82.21±17.89）μmol/L in severe pneumonia patients,mild pneumonia patients and healthy children respectively,furthermore,prevalence of vitamin D deficiency of the sever pneumonia group was significantly higher than that of the case-control group and normal group（P〈0.05,α=0.05）.The level of25（OH）D was not significantly related to CRP and PCT level in children with severe pneumonia（P〈0.05,α=0.05）.Conclusion The mean level of vitamin D in children with severe pneumonia was significantly lower,which may be associated with the occurrence and development of severe pneumonia in children.