摘要
TET2为TET家族成员之一,是一个与造血系统发育密切相关的肿瘤抑制基因。近年研究发现,TET2通过将DNA上的5-甲基胞嘧啶(5-mc)氧化为5-羟甲基胞嘧啶(5-hmc),参与DNA的去甲基化过程。体细胞中TET2基因异常会导致骨髓生成异常及恶性髓系疾病的发生。本文将就TET2的结构与功能,TET2基因突变与不同类型髓系肿瘤的关系进行综述。
TET2 gene is a member of TET oncogene family.It has been reported as a tumor suppressor gene with important roles in myelopiesis.Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine（ 5-mc） into 5-hydroxymethylcytosine（ 5-hmc）.Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies.In this review,the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.
作者
李荣
许明江
杨逢春
周圆
LI Rong XU Ming-jiang YANG Feng-chun ZHOU Yuan(State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, CAMS and PUMC, Tianjin 300020, Chin)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2016年第5期583-588,共6页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(81328003)
天津市应用基础研究重点项目(13JCZDJC31200)~~
关键词
TET2
突变
髓系肿瘤
TET2
mutation
myeloid malignancies
