脂肪细胞因子与2型糖尿病β细胞衰竭关系的研究进展

Advances in the Relationship between Adipokines and β-cell Failure in Type 2 Diabetes Mellitus

β细胞衰竭和胰岛素抵抗在2型糖尿病发病过程中发挥重要作用。循环中脂肪细胞因子的改变,可使肥胖、β细胞衰竭和胰岛素抵抗之间建立紧密联系。一部分脂肪细胞因子起有益作用,另一部分则是有害的,它们对于β细胞衰竭的贡献主要依赖于脂肪细胞因子间的相互作用。本文总结了瘦素、脂联素、抵抗素、内脏脂肪素等脂肪细胞因子在β细胞功能、增殖、死亡和衰竭中的作用,以期帮助今后对脂肪细胞因子与β细胞联合效应的深入研究,为2型糖尿病的治疗提供新的方向。

β-cell failure coupled with insulin resistance plays a key role in the development of type 2diabetes mellitus（ T2DM）.Changed adipokines in circulating level form a remarkable link between obesity and both β-cell failure and insulin resistance.Some adipokines have beneficial effects,whereas others have detrimental properties.The overall contribution of adipokines to β-cell failure mainly depends on the interactions among adipokines.This article reviews the role of individual adipokines such as leptin,adiponectin,and resistin in the function,proliferation,death,and failure of β-cells.Future studies focusing on the combined effects of adipokines on β-cells failure may provide new insights in the treatment of T2 DM.