缬沙坦联合苯磺酸左旋氨氯地平治疗201例高危高血压患者的疗效评价

Effect of valsartan combined with amlodipine in the treatment of 201 patients with high-risk hypertension

目的探讨缬沙坦联合苯磺酸左旋氨氯地平治疗高危高血压患者的临床疗效。方法选择常州市新北区春江人民医院2014年6月至2016年6月收治的201例高危高血压患者,随机分为治疗组（n=101）和对照组（n=100）。对照组采用苯磺酸左旋氨氯地平治疗,治疗组在对照组的基础上联合缬沙坦治疗。观察比较两组收缩压和舒张压水平、血钾和血肌酐浓度、SF-36评分及不良反应发生情况。结果治疗后,两组收缩压和舒张压水平均显著降低（P〈0.05）,且观察组低于对照组（P〈0.05）;治疗后4周,观察组收缩压和舒张压水平亦均显著低于对照组（P〈0.05）。治疗后,两组血K＋浓度、血肌酐浓度均显著降低（P〈0.05）,且观察组低于对照组（P〈0.05）;治疗后4周,观察组血K＋浓度和对照组无差异（P〉0.05）,血肌酐浓度亦低于对照组（P〈0.05）。两组SF-36评分均显著升高（P〈0.05）,且观察组显著高于对照组（P〈0.05）。观察组不良反应率为5.94%,对照组为8.00%,两组比较无统计学意义（χ~2=1.612,P=0.880）。结论缬沙坦联合苯磺酸左旋氨氯地平治疗高危高血压临床疗效显著,安全性高,可以有效改善患者生活质量,值得推广应用。

Objective To investigate the effect of valsartan combined with amlodipine in the treatment ot high-risk hypertension patients. Methods 201 patients with high-risk hypertension in our hospital from June 2014 to June 2016 were randomly divided into observation group （n= 101） and control group （n= 100） . The control group was treated with amlodipine, and the treatment group was treated with valsartan on the basis of the control group. It compared the level of systolic blood pressure and diastolic blood pressure, serum potassium （K＋ ）, serum creatinine concentration, SF-36 score and adverse reaction of the two groups. Results After treatment, the level of systolic blood pressure and diastolic blood pressure were significantly lower than those before treatment respectively （P〈0.05）, and both of them in the observation group were lower than those in the control group （P〈0.05） . After 4 weeks＇ treatment, the level of systolic blood pressure and diastolic blood pressure in observation group were significantly lower than those in control group （P〈0.05） . In addition, after treatment, the concentration of serum K＋ and serum creatinine were significantly decreased than those before treatment respectively （P〈0.05）, and both of them in the observation group were lower than those in control group （P〈0.05） . After 4 weeks＇ treatment, there was no significant difference in the concentration of serum K＋ between observation group and control group （P 〈0.05）, however, the concentration of serum creatinine was lower than that in control group （P〈0.05） . The SF-36 score in two groups were significantly increased than those before treatment （P〈0.05） . The SF36 score in observation group was significantly higher than that in control group （P〈0.05） . There was no significant difference in the rate of adverse reaction between observation group and control group （5.94%vs 8.00 % ; χ2 = 1. 612, P= 0. 880） . Conclusion It has a significant clinical efficacy and high safety of valsartan combined with amlodipine in the treatment of high-risk hypertension patients. This method can effectively improve the life quality of patients and is worth of being generalized.