人类病毒组的概念与作用

The concept and functions of human virome

人类病毒组作为微生物组的一个组成部分,对机体的内稳态和生理健康发挥着至关重要的作用。本研究简要回顾了病毒组的研究方法,着重从两方面介绍病毒组对人类机体的影响。第一个方面是作为传统的致病原,病毒组对人类致病。第二个方面是病毒组通过调节机体免疫系统及转录状态等途径,以非致病原的角色来影响宿主的生理过程,从而对人体健康产生影响。虽然近年来在人类病毒组方面的研究取得了长足的进步,但是依然有很多问题需要进一步的研究去解决。

The human virome is a component of the microbiome, and plays a vital important role in physical homeostasis and health. Here we reviewed some research methods for virome in brief, meanwhile shed light on the influence of virome on human＇s health. In addition to serving as the inherited pathogens, virome also effects human＇s bi＇ ology by means of immunomodulation and transcriptional regulation, etc. There has been significant progress in the research of human virome, nevertheless, there are still a lot of questions supposed to be solved.