菌群变化对类风湿关节炎的影响

Effect of microbiota on rheumatoid arthritis

目前,对于类风湿关节炎(rheumatoid arthritis,RA)发病机制的研究虽然并不完全清晰,但过去20多年的研究已经使我们对RA的了解增加了很多。遗传因素对RA有很大的影响,但不足以完全解释RA的发生。随着对菌群与RA关系的了解增多,使我们认识到可以利用调节人体菌群的方法,来改善宿主黏膜及更远处的免疫环境以改善RA。目前研究已表明,RA与多个部位的菌群都有一定的关系。本研究将以RA的发病机制与影响因素为基础,对人体口腔、肺部和肠道的菌群变化对类风湿关节炎的影响以及益生菌的治疗作用进行综述。

At present, although the pathogenesis of rheumatoid arthritis （RA） is not completely clear, the researches have increased our knowledge about RA over the past 20 years. Genes are important but rather insufficient to explain the development of majority of RA cases. As we are getting to know more about the relationship between bacteria and RA, it becomes possible for us to use the method of adjusting the human microbiota to improve the immune environment of the host and then to control RA. Present study has shown that RA has a certain relationship with the microbiota in several parts of human body. This article, based on the pathogenesis and influencing factors of RA, reviewed the effects of microbiota in human mouth, lung and intestine on RA, as well as the role of probiotics in the treatment.