小剂量米非司酮治疗子宫肌瘤60例临床效果观察

Clinical efficacy observation of small dose of mifepristone in treatment of 60 cases of uterine fibroid patients

目的探究应用小剂量米非司酮治疗子宫肌瘤的临床效果。方法选取2014年6月至2015年6月我院门诊子宫肌瘤患者60例作为本次研究对象,全部给予口服小剂量米非司酮进行治疗,治疗持续时间为3个月,对比治疗前、后患者临床症状改善情况、子宫体积和子宫肌瘤大小以及卵泡刺激素(FSH)、黄体生成素(LH)、雌激素(E_2)、孕酮(P)、泌乳素(PRL)和雄激素(T)的血清含量水平。结果治疗后,大部分患者月经量明显减少,经期缩短、痛经、下腹坠胀等临床症状均明显改善,部分患者贫血纠正,子宫体积和子宫肌瘤体积均明显缩小,差异具有统计学意义(P<0.05);血清中FSH、LH、E_2和P含量显著下降,差异具有统计学意义(P<0.05);PRL以及T的血清含量未发现明显变化,差异不具有统计学意义(P>0.05)。结论小剂量米非司酮用于治疗子宫肌瘤,能够取得较好的临床效果,可降低患者复发率,减少药物不良反应,适宜在临床中予以推广运用。

Objective To explore the clinical effect of small dose of mifepristone in the treatment of uterine fibroid. Methods Sixty cases of uterine fibroid patients admitted in the outpatient department of our hospital from June 2014 to June 2015 were selected as the research objects. All patients were treated with small dose of mifepristone orally, the treatment duration was three months. The improvement of clinical symptoms, the size of uterine volume and uterine fibroid, the level of FSH, LH,E2, P, PRL and T were compared. Results After the treatment, the menstrual blood loss reduced remarkably, and other clinical symptoms like menstrual period reduction, dysmenorrhea, lower abdomen bulge were improved remarkably, a part of patients with anemia was cured, the size of uterine volume and uterine fibroid were all shrinked, the difference was significant （P〈0.05）; the levels of FSH, LH, E2, P were reduced, the difference were significant （P〈0.05）. However, there was no statistical difference in PRL and T （P〉0.05）. Conclusion Small dose of mifepristone can achieve better clinical efficacy in treatment of uterine fibroid, with decreased recurrence rate, and less adverse drug reactions, which is suitable to apply in clinic.