蛋白激酶B(AKT)对哮喘发病影响研究

Research on the Effect of AKT on Asthma Attack

蛋白激酶B(PKB/AKT)是一种重要的蛋白激酶,在磷脂酰肌醇-3-激酶(PI3K)等信号转导通路中起重要作用,在细胞增殖分化、转录、翻译、细胞凋亡、运动、自我吞噬和新陈代谢等过程中扮演重要角色。支气管哮喘是以气道炎症、气道重塑、气道高反应性为主要病理特征的慢性炎症性疾病,其发病受多种因子和信号通路影响和调控,现就AKT的生物学效应和AKT在哮喘发病机制中的作用做出总结。

Protein kinase B（PKB/AKT）is an important protein kinase and plays a crucial role in phosphatidylinositol-3-kinase（PI3K）signal pathway. AKT protein kinase is confirmed to participate in regulate a series of physiological processes which include cell proliferation,differentiation,apoptosis,autophagy and metabolism. Allergic bronchial asthma is chronic inflammatory diseases characterized by airway inflammation,airway remodeling,mucous hypersecretion and airway hyperresponsiveness. It is well known that various factors and signal pathways could affect asthma attack. Now the auther will make a summary for AKT＇s biologic effect and impact on the pathogenesis of asthma.