生脉饮加减治疗糖尿病性下肢动脉硬化闭塞症临床疗效观察

Study on Clinical Effect of Shengmai Decoction in the Treatment of Diabetic Lower Extremity Arterial Occlusive Disease

目的:探讨生脉饮加减治疗糖尿病性下肢动脉硬化闭塞症临床疗效。方法:选取我院脉管病科诊断及治疗的糖尿病性下肢动脉硬化闭塞症患者114例,按随机数字表法分组,对照组患者57例予以常规治疗,研究组患者57例在常规西药治疗基础上予以生脉饮加减治疗,由专业人员检测下肢彩超结果及血液流变学指标,同时对比临床疗效及并发症状况。结果:对照组治疗有效率77.19%低于研究组治疗有效率91.23%,具有统计学意义(P<0.05);与治疗前比较,两组患者治疗后下肢彩超检测结果及血液流变学指标均发生变化,研究组治疗后腘动脉、股动脉以及足背动脉血管内径、峰值流速、血流量改善程度明显优于对照组,研究组患者治疗后全血高、低切黏度、红细胞比容、血浆黏度值低于对照组,具有统计学意义(P<0.05);两组间不良反应轻微,未作处理或经医务人员对症处理后短时间内缓解。结论:生脉饮加减治疗糖尿病性下肢动脉硬化闭塞症疗效确切,有效缓解下肢动脉血流情况,安全性高。

Objective：To investigate the clinical effect of Shengmai Decoction in the treatment of diabetic lower extremity arterial occlusive disease. Methods：114 cases with diabetic lower extremity arterial occlusive disease in endocrinology department in our hospital were selected and divided into 2 groups. 57 cases in the control group received conventional therapy,57 cases in the experiment group received more with Shengmai Decoction,lower extremity color Doppler ultrasonography and blood rheology index were detected by professional and clinical efficacy and complications were compared after the treatment. Results：The clinical efficacy in experiment group was 91.23%,which significant higher than that in control group 77.19%（P〈0.05）. Compared with before treatment,the detection results of lower limb and blood rheology indexes were changed,popliteal artery,femoral artery and dorsalis pedis artery blood vessel diameter,peak velocity,blood flow improvement in the experiment group were significantly better than the control group（P〈0.05）. Adverse reactions between the two groups were mild,and no treatment or after treatment by medical staff for a short period of time to ease. Conclusion：Shengmai Decoction in the treatment of diabetic lower extremity arterial occlusive disease was effective with safety,and it can effectively relief of lower extremity arterial blood flow.