高龄多囊卵巢综合征患者的卵巢储备特点及其助孕结局

Features of ovarian reserve and outcomes of assisted reproductive technology in elder patients with PCOS

35岁后多囊卵巢综合征(PCOS)患者的卵巢储备较之同龄人可能有一定的优势。在行辅助生育技术(ART)过程中,40岁前的获卵数往往高于同龄非PCOS人群,40岁以后PCOS患者同样有卵泡质量及胚胎发育潜能不足的问题,对ART助孕结局产生不利影响。现有资料表明,PCOS患者在40岁以后的临床妊娠率、活产率与同龄非PCOS人群的变化趋势一样,同时其代谢、内分泌因素对妊娠结局的负面影响仍然存在。

Patients with polycystic ovary syndrome（ PCOS） older than 35 yrs may possess a potential advantage of ovarian reserve compared with women of the same age. When assisted reproductive technology（ ART） is performed,PCOSpatients younger than 40 yrs usually have more retrieved oocytes than age-matched non-PCOS infertile patients. Nevertheless,age related decline in the quality of follicles and deficiency in fetal development adversely affect the outcomes of ART in PCOS patients thereafter. Data showthat PCOS patients have the same tendency of age-related decline in terms of clinical pregnancy rate and live birth rate,as with non-PCOS population of the same age,while metabolic and endocrine factors unfavorably influence pregnancy outcomes.