养血清脑颗粒对血管性痴呆的治疗价值探讨

Therapeutic Effect of Yangxue Qingnao Granules in Vascular Dementia Patients

目的:观察养血清脑颗粒对血管性痴呆(VD)患者的临床治疗效果。方法:收集86例VD患者,分为对照组40例和观察组46例。对照组给予抗血小板、控制血压、血糖、血脂、多奈哌齐抗痴呆,以及尼莫地平改善循环治疗,观察组在此基础上再予口服养血清脑颗粒4g tid,观察3个月。结果:3个月后,观察组简易智能量表得分显著高于对照组(P=0.013),临床痴呆程度评分(P=0.040)、日常生活能力评分(P=0.022)显著低于对照组。观察组总有效率较对照组明显提高(P=0.037)。治疗后,观察组大脑中动脉收缩期血流速度、平均血流速度、搏动指数均较对照组下降(P<0.05)。结论:养血清脑颗粒对VD患者具有显著疗效,可作为临床用药选择。

Objective ： To observe the therapeutic effect of Yangxue Qingnao Granules in patients with vascular dementia （YD）. Methods：Eighty- six patients with VD were collected and divided into two groups, including 40 in the control group and 46 in the observation group. The control patients were given the treatments including antiplatelet, controlling blood pressure, glucose and lipid control, donepezil and nimodipine. The observed cases were orally given Yangxue Qing- nao Granules 4 g three times a day besides the treatments of the controls. The observation lasted for 3 months. Results ： After treatment,the mini mental state examination score （ P = 0. 013 ） of the observation group was significantly higher than that of the control group. The clinical dementia rating （ P = 0. 040） and activity of daily living scores were lower than those of the control group（ P = 0. 022 ） . The total effective rate of the observation group＇ s patients was significantly high- er （ P = 0. 037 ）. The Vs, Vm and PI in the observation group became lower than thosc of the control group after treatment （P 〈0. 05）. Conclusion：Yangxue Qingnao Granules have significant curative effect on VD patients, which could be a choice in clinical treatment.