抗磷脂抗体综合征合并中枢神经系统疾病5例报道及文献复习

Antiphospholipid Syndrome with Central Nervous System Diseases in 5 Cases Report and Literature Review

目的:探讨抗磷脂抗体综合征(APS)中枢神经系统损害的临床表现及诊治特点。方法:回顾性分析APS合并中枢神经系统疾病患者5例的临床资料,结合文献进行分析。结果:5例抗磷脂抗体(aPL)均阳性,合并脑梗死2例,合并舞蹈病2例,合并癫痫1例,合并僵人综合征1例;治疗予以抗血小板、抗凝、抑制炎症、免疫抑制等,患者症状均得到改善。结论:神经系统受累的APS的诊断主要依据相关临床表现及a PL的检测,未有明确病因的神经系统疾病,可行a PL检测,有助于APS的诊治。

Objective： To investigate the clinical manifestations and characteristics of diagnosis and treatment of central nervous system damage in patients with antiphospholipid syndrome（APS）. Methods： Clinical data of five cases with APS complicated diseases of the central nervous system were retrospectively analyzed combining with literature analysis. Results： Five patients were positive for antiphospholipid antibody. Concomitant cerebral infarction was found in 2 cases, concomitance of chorea in 2 cases, concomitance of epilepsy in 1 case, concomitance of stiffman syndrome in 1 case. This group of patients was treated with antiplatelet, anticoagulant, inhibiting inflammation and immunosuppression. Patients＇ symptoms were alleviated. Conclusion： The diagnosis of APS with central nervous system diseases is mainly based on related clinical manifestations and main phospholipid antibody. Without a clear etiology, antiphospholipid antibody detection has important clinical significance for diagnosis and treatment against APS.