补体C1q在系统性红斑狼疮及狼疮肾炎诊断中的相关性研究分析

Correlation Analysis of Complement C1q in the Diagnosis of systemic Lupus Erythematosus and Lupus Nephritis

目的分析补体C1q在系统性红斑狼疮及狼疮肾炎诊断相关性研究。方法选择系统性红斑狼疮及狼疮肾炎患者40例,将其作为实验组;选择其他风湿性疾病和其他肾脏疾病患者40例,将其作为疾病对照组;并选择同期健康体检者40例,将其作为对照组,选择单向免疫扩散法来对研究对象的血液补体C1q进行测量。结果在血清补体C1q水平方面,实验组患者低于疾病对照组和对照组(P<0.05);另外活动期患者的血清补体C1q水平低于稳定期患者(P<0.05)。结论补体C1q水平和系统性红斑狼疮及狼疮肾炎患者的肾脏损害存在显著相关性,且稳定期患者的补体C1q明显高于缓解期患者,可将其当成狼疮肾炎患者病情活动性变化和治疗效果的评价指标,能为早期诊断和临床用药提供科学依据。

Objective Correlation analysis of complement C1 q in diagnosis of systemic lupus erythematosus and lupus nephritis. Methods 40 cases of systemic lupus erythematosus and lupus nephritis patients,as the experimental group,selection of other rheumatic diseases and other kidney diseases in 40 patients,as the disease control group; and 40 cases of healthy people were selected,the control group,select the unidirectional immunodiffusion method to study the blood complement C1 q measurement. Results in the serum complement C1 q level,the experimental group was lower than the disease control group（P〈0.05）; in addition,the serum complement C1 q level in the active phase was lower than that in the stable period（P〈0.05）. Conclusion The levels of complement C1 q and renal damage in systemic lupus erythematosus and lupus nephritis patients showed significant correlation,and patients with stable complement C1 q was significantly higher than that of patients in remission,the evaluation index as the disease activity in patients with lupus nephritis changes and treatment effect,can provide scientific basis for early diagnosis and clinical treatment.