肺炎支原体肺炎合并肺外表现患儿外周血辅助性T细胞表达水平分析

Expression of T helper cells in peripheral blood of children with Mycoplasma pneumonia complicated with extrapulmonary manifestations

目的分析肺炎支原体肺炎(MPP)合并肺外表现患儿外周血辅助性T细胞表达水平。方法选择2015年1月至12月在沈阳市儿童医院门诊就诊或住院治疗的MPP患儿97例,入选对象均在开始治疗前接受了外周血辅助性T细胞(CD3+、CD4+、CD8+、CD4+/CD8+)检测,并与同期体检结论正常儿童(对照组,35例)相同测试结果比较。结果 MPP组外周血CD3+、CD4+表达强度及CD4+/CD8+比值均明显低于对照组,而CD8+水平则明显高于后者,差异均有统计学意义(P<0.05)。97例MPP患儿中,合并肺外表现者43例(44.33%),合并肺外表现组外周血CD3+、CD4+水平、CD4+/CD8+比值均明显低于无肺外表现组,而CD8+水平则明显高于后者,差异均有统计学意义(P<0.05)。结论 MPP患儿存在着明确的外周血辅助性T细胞表达异常,合并肺外表现者变化更为显著。

Objective To analyze the expression level of T helper cells in peripheral blood of children with Mycoplasma pneumonia complicated with extrapulmonary manifestations. Methods We detected the peripheral T helper cells（CD3＋,CD4＋ ,CD8＋,CD4＋/ CD8＋）in the blood of the 97 selected continuous cases of children with Mycoplasma pneumoniae pneumonia before starting treatment,who received treatment in the Children Hospital of Shenyang from Jan. to Dec. 2015, and compared with the results of the normal children on the medical conclusions at the same test in the same period（control group,n=35）. Results The expression intensity of the peripheral CD3＋,CD4＋, and ratio of CD4＋ /CD8＋ of the Mycoplasrna pneumoniae pneumonia group were significantly lower than the control group, while that of CD8＋ was higher （P〈 0. 05- 0.01）. In the 97 children with Mycoplasma pneumoniae pneumonia, 43 cases had extrapulmonary manifestations（44.33%）, and the CD3＋level,the CD4＋level,CD4q- /CD8＋ ration in the group with extrapulmonary manifestations were obviously lower than the group without extrapulmonary manifestations, while the CD8＋ level was higher than the latter（P〈0. 05-0.01）. Conclusion Peripheral blood helper T cells are abnormally expressed in children with Mycoplasma pneumonia;these abnormalities are more obvious in the patients complicated with extrapulmonary manifestations.