胱抑素C与2型糖尿病大血管病变的关系

The Relationship Between Cystatin C and Macroangiopathy in Type 2 Diabetes Mellitus

目的探讨胱抑素C与2型糖尿病大血管病的关系。方法本实验收集正常人(NC)32例,单纯糖尿病(DM1)24例、糖尿病合并大血管并发症(DM2)32例,以及大血管病变(VD)30例,临床资料共118例。所有受试对象均隔夜空腹10小时以上,采空腹静脉血测定血脂,总胆固醇,甘油三脂,LDL,HDL,空腹血糖,糖化血红蛋白,h-CRP等指标,分离血清样本。用免疫比浊法比较各组患者的血清胱抑素C水平。结果(1)NC组,DM_1组,VD组,DM_2组,血清CysC水平依次增加,四组间比较,差异具有统计学意义(P<0.05),四个样本均数间两两比较,差异具有统计学意义(P<0.000 1)。(2)NC组,DM_1组,VD组,DM_2组,血清h-CRP水平依次增加,四组间比较,差异具有统计学意义(P<0.05),四个样本均数间两两比较,差异具有统计学意义(P<0.000 1)。(3)患者血清CysC水平与血清h-CRP水平显著正相关。结论(1)血清CysC水平与2型糖尿病大血管病变之间存在关联。(2)血清CysC水平与血清h-CRP水平显著正相关,提示CysC可能通过炎症过程参与2型糖尿病大血管病变的形成。

Objective To analyze the relationship between the plasma cystatin C and type 2 diabetes with macroangiopathy complications. Metheds This study was divided into 4 groups： NC was composed of 32 healthy control, DM1 was composed of 24 diabetes only, DM2 was composed of 32 diabetes with macroangiopathy complications, VD was composed of 30 patients only with macroangiopathy. 118 patients＇ blood samples were obtained in the morning after an overnight fast after 10 hours. The blood used to measure total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, HbA1C, FBG, C-reactive protein, cystatinC, ect. Plasma cystatinC were determined by particle enhanced turbidimetric immunoassay（PETIA）. Results（1）According to the sequence from low to high, the plasma cysctatinC levels were： NC, DM1, VD, DM2（P〈0.05）. The differences of the plasma cystatinC were statistically significant between random two groups among cases（P〈0.000 1）.（2） According to the sequence from low to high, the h-CRP levels were： NC, DM1, VD, DM2（P〈0.05）. The differences of the h-CRP were statistically significant between random two groups among cases（P〈0.000 1）.（3） The levels of plasma cystatinC were positively correlated to the h-CRP levels. Conclusion（1） There was a significantly correlativity between plasma cystatinC levels and type 2 diabetes with macroangiopathy complications.（2） A significant positive correlation between Serum cystatinC and h-CRP was found in this study. It is presumed that cystatinC was correlated with type 2 diabetes with macrovascular disease through inflammatory reaction.