壳聚糖及其衍生物在预防术后粘连方面的研究进展

Research Advances on Application of Chitosan and Its Derivatives in Postoperative Anti-Adhesion

术后粘连是外科手术中最常见的并发症之一,同时增加了再手术的难度和其他并发症的发生,因此预防术后粘连是外科领域亟待解决的一个难题。近年来各种抗粘连的药物和材料成为国内外专家研究的热点。壳聚糖具有成本低、方便使用、生物相容性良好、无细胞毒性等特点,其作为医用抗粘连材料有着巨大的潜力。本文从壳聚糖的来源、制备方法及其在抗粘连方面的研究进展做了概括总结。

The formation of peritoneal adhesions represents one of the most common complications after abdominal surgery, and it increases the difficulty of re - operation. Thus, preventing postoperative adhesions is a major problem in the field of surgical medicine. As a result, the study of anti - adhesion drugs and materials has become a hot topic for experts and scholars in recent years. The chitosan is inexpensive, highly biocompatible, nontoxic and easy to use, which make it a promising anti - adhesion material. Here, we reviewed the sources and preparation of chitosan and the research progress on preventing adhesion.