小汗腺汗孔癌5例临床表现及组织病理分析

Eccrine Porocarcinoma: a Report of Five Cases and Clinicopathological Study

目的了解小汗腺汗孔癌的临床特征及组织病理特点。方法对第四军医大学西京皮肤医院2007年4月-2015年8月经组织病理学检查确诊的5例小汗腺汗孔癌患者的临床及组织病理特点进行回顾性分析。结果 5例小汗腺汗孔癌患者中,男3例,女2例,平均年龄66.8岁,中位年龄69岁,平均病程1.5年。皮损部位:鼻部1例,颞部1例,下肢3例。临床表现多为结节及斑块,多数皮损伴有不同程度瘙痒、疼痛、糜烂及破溃。皮损组织病理可见排列紧密的团块状嗜伊红鳞状样细胞或基底样细胞,分布不典型,团块中央可见导管分化结构,细胞异型性明显。结论该病临床表现无明显特异性,确诊需要依靠组织病理检查。治疗上应早期予以手术切除皮损。若无转移病灶则预后较好。

Objective To illustrate the clinical and histopathologic features of eccrine porocarcinoma in 5 patients. Methods A retrospective study was performed to analyze the clinical and histopathologic data from 5 patients with eccrine porocarcinoma, who were treated in Xijing Hospital from April 2007 to August 2015. Results Demographic data showed that there were 3 male and 2 female patients diagnosed in this study. The mean age was 66. 8 years and the median age was 69 years. The average duration of the lesion was 1.5 years. The most common locations were nose, temporal region or the lower extremities. Most lesions presented as itchy and tender nodules or plaques, accompanied by erosion and ulceration. Histopathological study demonstrated that there were atypical, clumpy squamous cells or basaloid ceils, which arranged closely to form duct-like structures. Conclusion There was no specific clinical feature in eccrine porocarcinoma, while diagnosis was made by histopathological examination. Excision at early stage was recommended as first choice of the treatment. Metastatic diseases were associated with relatively poor prognosis.