上下肺叶放射敏感性的差异

The preliminary study of the radiosensitivity difference between superior and inferior lobes of the lung

目的:探讨上下肺叶的放射敏感性差异,以期指导放疗计划的设计和评估,并预测放射性肺损伤的发生概率。方法:回顾性分析106例接受3D-CRT治疗的胸部肿瘤病人,对比研究全肺、左右肺、上下肺叶的受照剂量与放射性肺损伤(radiation pulmonary injury,RP)发生的关系,用SPSS 17.0进行分析。结果:在RP^-、RP^+组中全肺、左右肺的受照剂量均无统计学差异(P>0.05)。上下肺叶的受照剂量存在统计学差异(P<0.05),且在RP-组和RP+组,上肺的受照剂量均较下肺高;HR=1.69。结论:下肺的放射敏感性比上肺高,在放疗计划的设计和评估中应考虑该因素的影响。

Objective： To study the differences of radiosensitivity between superior and inferior lobes of lung,to guide designment and evaluation of radiotherapy plans and predict the probability of radioactive pulmonary injury.Methods： All 106 thoracic tumor patient＇s information was analyzed retrospectively who have accepted 3D- CRT,and analyze the relation between radiation pulmonary injury（ RP） and dose exposed on total lung,left and right lung,superior and inferior lobes,respectively. The data were analyzed by SPSS 17. 0. Results： In the groups of RP^-and RP~＋,the doses exposed on left and right lung were not statistically different（ P〉0. 05）,but there were statistical differences between the doses exposed on superior and inferior lobes（ P〈0. 05）,and the doses exposed on the superior lobe were more than the inferior lobe,HR = 1. 69. Conclusion： The radiosensitivity of the inferior lobe is higher than the superior lobe,so we should consider this factor in the designment and evaluation of radiotherapy plan.