多孔载药纳米羟基磷灰石/聚酰胺/壳聚糖复合材料的制备与性能

Preparation and properties research of porous drug-delivery nano-hydroxy apatite/polyamide/chitosan composite materials

以纳米羟基磷灰石(n-HA)、聚酰胺(PA)、壳聚糖(CS)为原料,以聚乙烯吡咯烷酮(PVP)与氯化钠(Na Cl)为致孔剂采用溶液共混法和粒子致孔法,载入抗生素红霉素(EM),研制一种新型多孔载药纳米羟基磷灰石/聚酰胺/壳聚糖/红霉素复合骨组织修复材料。研究了其孔隙率、抗压强度、X射线衍射谱图、红外光谱图、SEM和药物释放曲线,探讨了CS含量及红霉素释放量对材料性能的影响。结果表明,当PVA/Na Cl为1:6时,材料总孔隙率为72%和抗压强度为0.71MPa,扫描电镜显示多孔n-HA/PA/CS复合材料孔的直径在100~500μm之间,适合血管、骨组织的长入以及营养物质的运输。当CS的含量从0增到30%时复合材料药物的释放量从41.6%增到82.4%,表明可降解材料CS的加入有利于药物溶出。

The new drug bone tissue repair material was prepared via the blending method and particle-induced hole method by using Nano-hydroxyapatite（ n-HA）,polyamide（ PA） and chitosan（ CS）. And polyvinylpyrrolidone（ PVP） and sodium chloride（ Na Cl）were porogen solution. The antibiotic erythromycin（ EM） was loaded in the composite solution of n-HA / PA / CS. The effects of CS content and the release of erythromycin were studied by testing its porosity,compressive strength,X-ray diffraction spectra,infrared spectra,SEM and drug release profile.The results showed that the porosity of drug porous material was 72%and overall compressive strength of 0. 71 MPa,scanning electron microscopy showed that between 100 - 500μm in diameter porous n-HA / PA / CS Composite hole for vessels,bone tissue ingrowth and transport nutrients,when the PVA / Na Cl was 1： 6. When CS content was increased from 0to 30%,the drug was released from 41. 6%to 82. 4%of the composite material,indicated that CS degradable material was added in favor of the drug＇s dissolution.