血清抵抗素、ox-LDL及MMP-9水平与老年ACI患者颈动脉斑块的关系

Relationship between levels of serum resistin, ox-LDL and MMP-9 and carotid artery plaque in senile patients with ACI

目的观察血清抵抗素、氧化低密度脂蛋白(ox-LDL)及金属蛋白酶-9(MMP-9)水平与老年急性脑梗死(ACI)患者颈动脉斑块的关系。方法分析医院收治的120例老年急性脑梗死住院患者,根据颈动脉内膜中层(IMT)厚度分为IMT正常组60例,斑块组60例;另选取同期正常健康体检者30例为健康组。采用酶联免疫吸附法(ELISA)测定各组血清抵抗素、ox-LDL及MMP-9水平。结果 IMT正常组TC、TG、HDL-C分别与斑块组和健康组比较,差异均无统计学意义(P>0.05);斑块组BMI、TC、TG显著高于健康组,而HDL-C显著低于健康组(P<0.05)。斑块组血清抵抗素、ox-LDL和MMP-9水平均显著高于IMT正常组和健康组(P<0.05),而IMT正常组又显著高于健康组(P<0.05)。Spearman相关性分析显示,斑块组血清抵抗素及ox-LDL水平与血清MMP-9水平呈正相关,而血清抵抗素与ox-LDL亦呈明显正相关。结论血清抵抗素、ox-LDL和MMP-9水平可在一定程度上反映老年脑梗死患者颈动脉斑块严重程度,可作为诊断老年颈动脉形成的重要参考指标。

Objective To explore the relationship between the levels of serum resistin, oxidized low-density lipoprotein（ox-LDL）and matrix metalloproteinase-9（MMP-9） and carotid artery plaque in senile patients with acute cerebral infarction（ACI）. Methods A total of 120 senile patients suffering ACI to receive treatment in our hospital were divided into normal-IMT group and plaque group（n = 60, respectively） according to the carotid intima-media thickness（IMT）, and another batch of persons in normal healthy condition were selected to constitute a health group（n = 30）. Enzyme-linked immunosorbent assay（ELISA） was adopted for determining the levels of serum resistin, ox-LDL and MMP-9. Results Compared with those in the plaque group and the health group, the TC, TG,and HDL-C in the normal-IMT group has no significant differences（P〉 0.05）; the BMI, TC, and TG in the plaque group were significantly higher than those in the health group, while the HDL-C was significantly lower than that in health group（P〉 0.05）. The average levels of serum resistin, ox-LDL and MMP-9 in the plaque group were significantly higher than those in the normal-IMT group and the health group（P 〉0.05）, and those in the normal-IMT group were significantly higher than those in the health group（P〈 0.05）.Spearman correlation analysis showed that in the plaque group the serum resistin and ox-LDL kept a positive correlation with the MMP-9 and serum resistin kept a positive correlation with the ox-LDL. Conclusion The serum resistin, ox-LDL and MMP-9 can reflect the severity of carotid artery plaque in senile patients ACI, so they can be used as an important reference index in the diagnosis on senile carotid artery plaque.