美沙酮维持治疗海洛因依赖病人的疼痛与生活质量的关系

PAIN AND ITS ASSOCIATION WITH QUALITY OF LIFE IN HEROIN-DEPENDENT PATIENTS RECEIVING METHADONE MAINTENANCE TREATMENT

目的:分析美沙酮维持治疗海洛因依赖病人的疼痛与生活质量的关系。方法:603例美沙酮维持治疗门诊海洛因依赖病人完成中文版世界卫生组织生活质量量表简表、匹兹堡睡眠质量指数、Zung氏抑郁自评量表、Zung氏焦虑自评量表和疼痛严重程度及功能损害评估;用协方差分析检验疼痛是否与海洛因依赖生活质量量表四领域评分显著独立相关。结果:海洛因依赖病人一般疼痛和临床显著疼痛检出率分别为64.3%和14.1%;临床显著疼痛组的生活质量量表四领域评分显著低于一般疼痛组,一般疼痛组的生活质量量表四领域评分又显著低于无疼痛组,调整协变量后,上述关系仍然具有统计学意义。结论:美沙酮维持治疗海洛因依赖病人疼痛问题检出率高,疼痛是美沙酮维持治疗海洛因依赖病人生活质量变差的显著危险因素,疼痛治疗有助于改善海洛因依赖病人的生活质量。

Objective：To analyze the relationship between pain and quality of life （QOL） among methadone-maintained heroin dependent patients. Methods： Six hundred and three heroin addicts were recruited from methadone maintenance treatment （MMT） outpatients, and administered with a Chinese edition of the World Health Organization＇s QOL Questionnaire-Brief Version （WHOQOL-BREF）, Pittsburgh Sleep Quality Index, Zung＇s Self-rating Scale for Depression, and Zung＇s Self-rating Scale for Anxiety. Analysis of covariance was used to test whether pain was significantly associated with all four QOL-domain scores of WHOQOL-BREF. Results： The rates of general and clinically significant pain （CSP） among MMT heroin addicts were 64.3% and 14.1%, respectively. Patients of CSP group had significantly lower scores than general pain group and general pain group lower than no pain group, in terms of four QOL-domain scores of WHOQOL-BREF. After adjustment for potential covariates, such relationship, overall, remained statistically signi？cant. Conclusion： Heroin addicts under MMT have high prevalence of pain. Pain acts as a signi？cant risk factor for addicts’ worsen QOL. Treating pain may improve the QOL of MMT heroin addicts.