Wnt信号通路在肿瘤调控方面的研究进展

Research progress on role of Wnt signaling pathway in regulation of tumors

Wnt信号通路是一条进化上十分保守的信号通路,控制着细胞的生长、分化、凋亡和自我更新。在肿瘤的发生发展中,该通路常常异常激活,并能够和其他信号通路协同或拮抗调节肿瘤的增殖、迁移和侵袭。该文主要对Wnt信号通路的研究进展及其在各类肿瘤生长调控中的作用进行简要综述。

Wnt signaling pathway is a highly conservative signal pathway controlling cell growth,differentiation,apoptosis and self-renewal. This signal pathway is often abnormally activated in tumor development and progression,which can cooperate or antagonize with other signal pathways to regulate tumor proliferation,migration and invasion. This paper makes a review of the recent research of Wnt signaling pathway progression and its function in tumor growth regulation.