正念减压对乳腺癌干预效果的Meta分析

Effects of mindfulness-based stress reduction on breast cancer: a Meta-analysis

目的:系统评价正念减压疗法(MBSR)对乳腺癌患者干预效果的影响。方法:计算机检索Pub Med、The Cochrane Library、EMBASE、Springer Link、Science Direct、四大中文库CBM、中国知网CNKI、维普和万方数据库中有关正念减压对乳腺癌患者研究的对照试验,检索截止2015年12月,并追溯纳入研究的参考文献。按照纳入和排除标准筛选文献对符合纳入标准的研究进行质量评价,并从中提取数据。采用Review Manager 5.3软件进行Meta分析,试验序贯分析估算各结局指标期望信息量(required information size,RIS)。结果:共纳入8项,其中4项随机对照试验,4项自身前后对照研究,合计381例患者。Meta分析结果显示:正念减压组在减轻知觉压力和缓解抑郁情绪方面均显著性优于常规护理组,但在焦虑方面无显著性差异。结论:正念减压可减轻患者的知觉压力,改善抑郁情绪,建议临床推广使用。

Objective: To systematically assess the effect of mindfulness-based stress reduction( MBSR) on patients with breast cancer. Methods: Pub Med, The Cochrane Library, EMBASE, Springer Link、Science Direct,CBM, CNKI, VIP and Wanfang database were searched through computer to single out relevant controlled trials( CTs) which investigated the effect of MBSR on patients with breast cancer; the deadline of retrieval was by the end of December 2015,and the references in the study were traced back. The literatures were screened out according to inclusion and exclusion criteria; the quality of studies meeting inclusion criteria was accessed and the data was selected from them. Meta-analysis was performed by using Rev-Man 5. 3 software,and trial sequential analysis was applied to estimate the required information size( RIS). Results: Eight studies were incorporated into Meta-analysis,including four randomized controlled trials and four self-controlled study with a total of 381 patients. The Meta-analysis findings indicated that the MBSR group was significantly superior to routine nursing group in reducing the perceived stress and relieving depression. Nevertheless,no significant difference was found in anxiety between the two groups. Conclusion: MBSR can reduce perceived stress and improve depression in patients with breast cancer,which is worthy of clinical promotion and application.