补阳还五汤联合胞磷胆碱胶囊治疗气虚血瘀型脑梗死后血管性痴呆临床效果分析

Clinical Effect of Buyang Huanwu Decoction Combined with Citicoline Capsule on Vascular Dementia after Cerebral Infarction of Qi Deficiency and Blood Stasis Type

目的分析中西医结合治疗气虚血瘀型脑梗死后血管性痴呆临床效果。方法方便选取2015年10月—2016年10月在莆田平民医院与莆田市第一医院就诊98例气虚血瘀型脑梗死后血管性痴呆患者,随机分为对照组和实验组,每组49例患者;对照组口服胞磷胆碱胶囊治疗,实验组在对照组治疗基础上,联合中药汤剂治疗;对比分析两组中医症候积分、MMSE、ADL得分和临床治疗效果。结果在治疗前两组中医症候积分差异无统计学意义(P>0.05);在治疗后,对照组与实验组中医症候积分分别为(43.58±2.63)分和(33.23±2.65)分。在治疗前MMSE评分和ADL评分两组之间差异无统计学意义(P>0.05);治疗后,实验组MMSE评分为(25.78±2.9)分,ADL评分为(85.74±7.04)分;均显著的高于对照组评分(P<0.05)。对照组中,有12例无效,有37例有效和显效,有效率为75.51%;实验组中,有7例无效,有42例有效和显效,有效率为85.71%;实验组有效率显著的高于对照组,差异有统计学意义(P<0.05)。结论中西医结合治疗脑梗死后血管性痴呆,可以显著的提高患者的精神状况和生活质量,临床治疗效果较好,在临床中具有推广和应用价值。

Objective To analyze the clinical effect of integrated traditional Chinese and western medicine on vascular dementia after cerebral infarction with Qi deficiency and blood stasis type. Methods Convenient from October 2015 to October2016 in our hospital 98 patients with vascular dementia after Qi deficiency and blood stasis cerebral infarction were randomly divided into control group and experimental group, each group of 49 patients; the control group orally The study group was treated with the traditional Chinese medicine decoction on the basis of the control group. The TCM syndrome score, MMSE, ADL score and clinical treatment effect were compared and analyzed. Results There was no significant difference in TCM syndrome scores between the two groups before treatment（P〉0.05）. After treatment, the scores of TCM symptoms in the control group and the experimental group were（43.58 ± 2.63）points and（33.23 ± 2.65）points, respectively.There was no significant difference between the MMSE and ADL scores before treatment（P〉0.05）. After treatment, the MMSE score of the experimental group was（25.78 ± 2.9）points and the ADL score was（85.74 ± 7.04）points Significantly higher than the control group score（P〈0.05）. In the control group, 12 cases were ineffective, 37 cases were effective and markedly effective, the effective rate was 75.51%; in the experimental group, 7 cases were ineffective, 42 cases were effective and markedly effective, the effective rate was 85.71%; the experimental group, Which was higher than that in the control group.the difference statistically significant（P〈0.05）. Conclusion Integrative Chinese and western medicine treatment of vascular dementia after cerebral infarction, can significantly improve the mental state of life and quality of life, clinical treatment is better, in the clinical application and promotion.