丙戊酸钠与左乙拉西坦治疗小儿癫痫68例分析

Analysis of 68 Cases of Infantile Epilepsy Valproate and Levetiracetam Treatment

目的研究丙戊酸钠与左乙拉西坦治疗小儿癫痫的临床疗效。方法整群选择2014年2月—2016年4月来该院治疗的小儿癫痫病患儿68例,采用随机分组的方式分为观察组和对照组,每组患儿34例。观察组患儿使用左乙拉西坦进行治疗,对照组患儿使用丙戊酸钠进行治疗,治疗4个月后,对比两组患儿S100β及血清神经元特异性烯醇化酶(NSE)水平,同时对比两组患儿治疗效果,以及治疗期间发生不良反应的几率。结果治疗前两组患儿在S100β、NSE水平差异无统计学意义(P>0.05),治疗后,观察组患儿S100β、NSE水平分别为(0.32±0.11)μg/L和(11.03±1.82)μg/L,低于对照组患儿的(0.74±0.26)μg/L和(21.84±3.15)μg/L;治疗总有效率为94.12%,高于对照组患儿的70.59%,不良反应发生率为2.94%,低于对照组患儿的23.53%,差异有统计学意义(P<0.05)。结论使用左乙拉西坦治疗小儿癫痫,临床治疗效果优于丙戊酸钠。

Objective To study the clinical effect of sodium valproate and levetiracetam in children with epilepsy. Methods Group selection 68 cases of children with epilepsy in children from February 2014 to April 2016 to the hospital for treatment, were randomly divided into observation group and control group, 34 cases in each group. The observation group used levetiracetam were the treatment, patients in the control group using sodium valproate treatment, after 4 months of treatment,compared two groups of S100 beta and serum neuron specific enolase（NSE） levels, and the treatment effect of two groups were compared, and the risk of adverse events during the treatment. Results Treatment The first two groups in the S100 beta, level of NSE showed no significant difference（P〈0.05）. After treatment, the observation group with S100 beta, NSE level respectively（0.32 ± 0.11）μg/L and（11.03 ± 1.82）μg/L, below the control group（0.74 ± 0.26）μg/L and liter（21.84 ±3.15）μg/L; the total effective rate was 94.12%, 70.59% higher than that of the control group, the incidence of adverse reaction was 2.94%, lower than that in the control group 23.53%, the difference was statistically significant（P〈0.05）. Conclusion The use of levetiracetam in children with epilepsy, clinical curative effect is better than sodium valproate.