肠脂肪酸结合蛋白表达水平在早期诊断新生儿坏死性小肠结肠炎中的意义

The meaning of expression level of intestinal fatty acid binding protein to early diagnosis of neonatal necrofizing enterocolitis

目的:探讨肠脂肪酸结合蛋白(I-FABD)表达水平对早期诊断新生儿坏死性小肠结肠炎(NEC)的意义。方法:选取收治的58例诊断为疑似新生儿坏死性小肠结肠炎患儿为试验组,以58例非新生儿坏死性小肠结肠炎患儿为对照组,以ELISA法测定患儿血清中I-FABD表达水平,以SPSS16.0软件进行统计学分析分析。结果:试验组患儿血清中I-FABP水平明显高于对照组患儿血清中I-FABP水平,差异有统计学意义(P<0.05)。结论:肠脂肪酸结合蛋白(I-FABP)可作为早期诊断新生儿坏死性小肠结肠炎(NEC)较准确的生物学指标。

Objective To explore the use of intestinal fatty acid binding protein（ I-FABP） expression level in the diagnosis of neonatal necrofizing enterocolitis（ NEC）. Method 58 newborns who were diagnosed as suspected neonatal necrotizing enterocolitis were selected as the experimental group,while 58 newborns without neonatal necrotizing enterocolitis were set as the control group. The contents of I-FABP in the serum were measured by ELISA and analyzed by SPSS16. 0 software for statistical analysis. Results Newborns in the experimental group showed significantly higher serum I-FABP levels than newborns in the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Intestinal fatty acid binding protein（ I-FABP） can be used as accurate biological indicators for early diagnosis of neonatal necrotizing enterocolitis（ NEC）.