布-加综合征患者检测血清FT3、FT4、TSH及凝血因子Ⅷ、Ⅸ水平的临床意义

Clinical significance of serum levels of FT3,FT4,TSH and coagulation factor Ⅷ,Ⅸ in Budd-Chiari syndrome patients

目的探讨血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、超敏促甲状腺素(TSH)及凝血因子Ⅷ、Ⅸ(FⅧ、FⅨ)在布-加综合征(Budd-Chiari syndrome,BCS)患者中的检测意义。方法采用病例-对照研究方法,对89例BCS患者和30名健康体检者分别进行FT3、FT4、TSH、FⅧ、FⅨ检测,采用独立样本t检验对两组均值进行比较。结果 BCS患者FT3、FT4、TSH、FⅧ及FⅨ活性(FⅧ∶C、FⅨ∶C)的水平分别为(4.36±1.17)pmol/L、(16.67±3.70)pmol/L、(3.08±3.02)m IU/L、(106.13±39.48)%和(88.90±45.69)%,与对照组比较,差异均无统计学意义(P>0.05)。结论血清FT3、FT4、TSH及血浆FⅧ∶C、FⅨ∶C水平的变化在我国BCS的发病因素研究中可能无明确的临床意义。

Objective To investigate the significance of serum levels of FT3,FT4,TSH and coagulation factor Ⅷ,Ⅸ（FⅧ,FⅨ） in Budd-Chiari syndrome（BCS） patients. Methods The case-control study method was used to compare the blood levels of free triiodothyronine（FT3）,free thyroxine（FT4）,thyroid-stimulating hormone（TSH） and coagulation factor Ⅷ,Ⅸ clotting activity（FⅧ∶ C,FⅨ∶ C） in 89 patients with BCS and 30 healthy controls retrospectively.Means were compared by t-test between two groups. Results Serum levels of FT3,FT4,TSH,FⅧ∶ C and FⅨ∶ C in BCS patients were（4. 36 ± 1. 17） pmol/L,（16. 67 ± 3. 70） pmol/L,（3. 08 ± 3. 02） m IU/L,（106. 13 ± 39. 48） %and（88. 90 ± 45. 69） %,respectively,there was no statistical significance compared with the controls（P〉0. 05）.Conclusion Clinical significant related to the serum levels of FT3,FT4,TSH,FⅧ∶ C and FⅨ∶ C may be unclear in the etiology research of patients with BCS in China.