MicroRNA在胰腺癌中的研究进展

Progess of microRNA in pancreatic cancer

胰腺癌起病隐匿,进展迅速,预后极差,目前仍缺乏有效的治疗手段。早期手术治疗是根治胰腺癌的唯一治疗方法,因此迫切需要寻找针对胰腺癌有效且新型的诊断、判断预后和治疗的工具。大量研究显示microRNA在胰腺导管腺癌(pancreatic ductal adeno-carcinoma,PDAC)中表达异常,在肿瘤的发生、发展、转移及治疗耐受方面都发挥重要作用。

Pancreatic cancer is a kind of common digestive tumor with less clinical manifestation,aggressive biological behavior and poor prognosis. We are still lack of effective treatment to cure it at present,and early surgery is the only method that we can do. So it＇s urgent to find an effective and new-style tool for the diagnosis,prognosis and therapy of pancreatic cancer. A lot of studies have shown abnormal expression of microRNA in pancreatic ductal adenocarcinoma（PDAC）,and microRNA play an important role in the initiation,progession,metastasis and drug-resistance of pancreatic cancer.