鼻咽癌患者血清VEGF和MMP-9水平的变化及其临床意义

Changes and clinical significance of serum VEGF and MMP-9 levels in patients with nasopharyngeal carcinoma

目的:探讨鼻咽癌患者血清血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)水平的变化及其临床意义。方法:收集50例鼻咽癌患者和20例健康对照者血清,采用luminex技术检测血清中VEGF及MMP-9水平变化,分析其与患者临床病理特征的关系。结果:鼻咽癌患者血清VEGF、MMP-9水平明显高于正常健康者(P<0.01),患者血清VEGF、MMP-9水平与患者年龄、性别及肿瘤分化程度无关(P>0.05),而与肿瘤淋巴结转移、远处转移、临床分期明显相关(P<0.01)。结论:检测血清VEGF、MMP-9水平对判断鼻咽癌患者病情进展和评估预后有一定的参考价值。

Objective： To explore the changes and clinical significance of vascular endothelial growth factor（ VEGF） and matrix metalloproteinase-9（ MMP-9） levels in serum of nasopharyngeal carcinoma（ NPC） patients.Methods： The serum VEGF and MMP-9 levels of 50 NPC patients and 20 healthy controls were measured by using luminex technology.Associations between the two markers and clinicopathologic features were further analyzed.Results： The serum VEGF and MMP-9 levels of NPC patients were obviously higher than those of healthy controls（ P 〈 0.01）.There was no correlation of the serum VEGF and MMP-9 levels with NPC patients’ age,gender and degree of tumor differentiation（ P 〉 0.05）.A significant relationship was found between the serum VEGF and MMP-9 levels and the lymph node metastasis,distant metastasis and clinical stage（ P 〈 0.01）.Conclusion： The serum VEGF and MMP-9 levels may be useful for evaluating the progress and prognosis of NPC patients.