抗抑郁药在消化性溃疡中的应用

Influence of antidepressant drugs for peptic ulcer

进入21世纪以来,随着生活节奏的加快和受不良因素的影响,全球消化性溃疡的发生率和致死率逐年上升,严重影响人们的健康和生活质量。传统西医防治消化性溃疡主要采取抑酸制剂、黏膜保护剂及抗生素联合应用的方案,不能解决其复发的问题。消化性溃疡是一种常见的心身疾病,精神心理因素对该病的发生有重要影响,多种抗抑郁药已被用于消化性溃疡的治疗。本文总结近年来常用抗抑郁药治疗消化性溃疡的临床研究,为消化性溃疡的治疗提供新的思路。

Since entering the 21 century, with the accelerated pace of life and the influence of adverse factors, the global incidence and fatality rate of peptic ulcer （PU） increased year by year, the people＇s health and quality of life were seriously affected. In traditional western medicine, prevention and treatment of peptic ulcer mainly took combination method of acid suppression agents, mucosal protective agent and antibiotics, which couldn＇ t solve the problem of recurrence. PU is a common psychosomatic disease, psychological factor plays an important role in the occurrence of PU, a variety of antidepressant drugs have been used for the treatment of PU. This article summarizes clinical research about commonly used antidepressant drugs in the treatment of PU in recent years, and to provide a new idea for the treatment of PU.