摘要
目的探讨老年人原发性胆汁性胆管炎的临床特征。方法原发性胆汁性胆管炎患者,共121例,分为老年组及非老年组,老年组44例,非老年组77例;收集并比较两组PBC患者的临床资料、检验及影像检查资料。结果老年组中临床症状发生率最高的是乏力、黄疽,非老年组中为乏力、纳差,组间比较临床症状发生率差异不显著;老年组的TBIL、DBIL、ALT、AST、ALP、GGT平均值均略高于非老年组,但差异无统计学意义;自身免疫抗体检验结果显示,PBC患者检出率最高的是AMA、AMA-M2及ANA抗体。老年组中AMA、AMA-M2、Gp210、Sp100的检出率略高于非老年组,ANA的检出率低于非老年组,但差异无统计学意义。结论老年人原发性胆汁性胆管炎确诊晚,发现时大部分均已进入症状期以后,表现为乏力、黄疽、纳差等,肝硬化、腹水的发生率高。但与非老年组相比差异不显著。
Objective To discuss the clinical characteristics of primary billiary cholangistis in elderly patients. Methods 121 patients with primary billiary cholangistis were enrolled in the study: 44 cases in elderly group and 77 cases in non- elderly group; the clinical data of the cases in the 2 groups were collected and analyzed. Results The highest occurrences of clinical symptoms in elderly group were fatigue and jaundice while those in non-elderly group were fatigue and poor ap- petite, the difference between the 2 groups was of no statistical significance; the average values of TBIL, DBIL, ALT, AST, ALP and GGT of the patients in elderly group were slightly higher than those in non-elderly group, the difference between the 2 groups was of no statistical significance; the detection rates of AMA, AMA-M2, Gp210 and Spl00 in elderly group were slightly higher than those in non-elderly group while the detection rate of ANA in elderly group was lower than that in non-elderly group, the differences between the 2 groups were of no statistical significance. Conclusions The diagnosis of primary billiary cholangistis in the elderly is often confirmed late, usually until the onset of symptoms: fatigue, jaundice and poor appetite, the occurrences of cirrhosis and ascites are high, but there exists no obvious difference between the elderly patients and the non-elderly patients.
出处
《老年医学与保健》
CAS
2016年第6期352-354,共3页
Geriatrics & Health Care
基金
国家自然科学基金(81402559)
关键词
原发性胆汁性胆管炎
老年人
临床特征
Primary billiary cholangistis
Elderly
Clinical characteristics