骨化性气管支气管病临床病理特点并文献复习

Traeheobrochopathia osteochondroplastica:clinicopathological features and literature review

目的探讨骨化性气管支气管病的临床病理特点。方法回顾性分析1例骨化性气管支气管病患者的临床、实验室检查、影像学及病理学特征并文献复习。结果骨化性气管支气管病临床表现无特异性,高分辨CT扫描前、侧壁可见点状高密度影,后壁(膜部)无高密度影,气管镜表现为支气管开口处见多发结节病灶,结节病理活检示黏膜下骨化、慢性炎症细胞浸润,表面呼吸上皮鳞状上皮化生伴轻度不典型增生。结论骨化性气管支气管病比较少见,高分辨CT具有提示意义,支气管镜下表现具有特征性,其确诊需结合病理活检。

Objective To investigate the elinicopathological features of traeheobrochopathia osteochondroplastica. Methods The clinical manifestations, laboratory findings, imaging and pathological features of one patient with traeheobrochopathia osteochondroplastica were retrospectively analyzed, and the related literatures were reviewed. Results The clinical manifestations of traeheobrochopathia osteochondroplastica were not specific. High-resolution CT indicated point-like high density shadow of anterior and side wall, which was not found in posterior wall （membrane）. Bronchoscopic examination revealed multiple nodules at the opening of the bronchus. The biopsy of the nodules demonstrated submucosal ossification, chronic inflammatory infiltration, and squamous metaplasia of the surface respiratory epithelia with mild atypical hyperplasia. Conclusion Traeheobrochopathia osteochondroplastica is a rare disease. High-resolution CT has significant clue to the diagnosis, and there are characteristic presentations under bronchoscope. Pathological biopsy is needed to confirm the diagnosis.