期刊文献+

微栓子联合血浆D-二聚体水平与房颤栓塞危险的关系 被引量:2

下载PDF
导出
摘要 目的 :观察房颤患者微栓子和D-二聚体水平与血栓栓塞危险分层的关系。方法 :300例持续性房颤患者,监测微栓子及检测D-二聚体水平,同时参考房颤栓塞临床危险分层给每例评分,依据微栓子是否阳性及D-二聚体水平是否高于正常单独及联合分组,比较各组临床评分。结果:微栓子监测阳性78例,阴性222例,两组非瓣膜病性房颤患者存在的危险因素评分(CHADS2)分别为(3.8±1.1)分和(2.6±1.0)分(P<0.05);血浆D-二聚体阳性107例,正常193例,两组CHADS2评分分别为(3.4±1.2)分和(2.8±1.3)分(P<0.05)。微栓子阳性同时D-二聚体阳性(A组)48例,微栓子阳性同时D-二聚体正常(B组)30例,微栓子阴性同时D-二聚体阳性(C组)59例,微栓子阴性同时D-二聚体正常(D组)163例,各组CHADS2评分分别为A组(3.6±1.3)分、B组(3.3±1.2)分、C组(3.2±1.3)分、D组(2.6±1.2)分,4组间评分结果有显著性差异(F=5.20,P=0.002),A组评分高于其他3组,与D组差异有统计学意义(P<0.05);微栓子监测与D-二聚体水平存在关联性(χ2=30.74,P<0.05,r=0.32)。结论 :房颤患者微栓子阳性以及D-二聚体阳性与较高的CHADS2评分一致;微栓子监测与D-二聚体检查联合可在CHADS2评分基础上协助评估房颤患者栓塞风险。
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2016年第12期1500-1501,1560,共3页 Journal of Nanjing Medical University(Natural Sciences)
基金 苏州市科技局指令性项目(SYS201305)
  • 相关文献

参考文献1

二级参考文献12

  • 1夏小杰,昝沁,陈红,孙安琼,杨俊芬,黄元铸,曹克将,许香广,胡雪松.心房颤动患者血浆纤维蛋白原、D-二聚体浓度及t-PA活性变化的研究[J].医师进修杂志,2005,28(1):18-21. 被引量:4
  • 2Fustcr V, Rycen LE, Caunom DS, et al. ACC/AHA/ESC 2006 Guidelines lot the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Commi tee for Practice Guidelines (Writing Committee to Revisc the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) : developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulzttion ,2006,114 : e257-354.
  • 3[No authors]. Basic identification criteria of Doppler microembolic signals. Conseasus Committee of the Ninth International Cerebral Hemodynamic Symposium. Seroke, 1995,26 : 1123.
  • 4Co AS, Hylek EM. Chang Y, et al. Antieoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice? JAMA, 2003, 290: 2685- 2692.
  • 5Estes NA 3rd, Halperin JL, Calkins H, et al. ACC/AHA/ Physician Consortium 2008 Clinical Performance Measures for Adults with Nonvalvular Atrial Fibrillation or Atrial Flutter: a report of the American Colege of Cardiology/American Heart Association Task Force on Performanee Measures and the Physician Consortium for Performance hnprovcment (Writing Committee to Develop Clinical Performance Measures for Atrial Fibrillation ) Developed in Collaboration with the Heart Rhythm Society. J Am Cull Cardiol, 2008,51:865-834.
  • 6European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Ringleb PA,et al. Guidelines for management of ischaemic struke and transient isehaemic attack 2008. Cerebrovasc Dis, 2008,25:457-507.
  • 7Mahe I, Drouet L, Simoneau G, et al. D-dimer can predict survival in patients with chronic atrial fibrillation. Blood Coagul Fibrinolysis,2004,15:413-417.
  • 8Habara S, Dote K, Kato M, et al. Prediction of left atrial appendage thrombi in non-vahular atrial fibrillation. Eur Heart J, 2007,28 : 2217-2222.
  • 9Nozawa T, Inotte H, Hirai T, et al. D-dimer level influences thromboembolie events in patients with atrial fibrillation. Int J Cardiol, 2006,109:59-65.
  • 10Sauren LD, la Meir M, de Roy L, et al. Increased number of cerebral emboli during percutaneous endocardial puhnonary vein isolation versus a thoracoscnpic epicardial approach. Eur J Cardiothorae Sung, 2009,36:833-837.

共引文献2

同被引文献19

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部