摘要
目的:探讨经鼻气道持续正压通气(nCPAP)对 OSAHS患者夜尿次数增多的改善作用。方法选择2014年6月至2016年5月夜尿次数增多的中重度 OSAHS 患者74例,其中中度[15次/h≤呼吸暂停低通气指数(AHI)〈30次/h]14例、重度(30次/h≤AHI〈60次/h)31例和极重度(AHI≥60次/h)29例,进行 Auto-nCPAP滴定、记录 n-CPAP滴定当晚平均压力及治疗前后夜尿次数,并对其结果进行统计学处理。结果 OSAHS 患者夜尿次数与 AHI、ESS 评分、夜间最低血氧饱和度(LSpO2)相关(r=0.728、0.435、-0.293,P 值均〈0.05),且随着 AHI 增大,夜尿次数逐渐增多;nCPAP治疗后夜尿次数明显减少,3组治疗前后P值均〈0.001,且当晚 nCPAP 压力与夜尿次数呈正相关(r=0.503,P〈0.001),nCPAP压力〈9 cmH2 O 患者夜尿次数明显比 nCPAP压力≥9 cmH2O 组少,差异有统计学意义(1.30±1.10 vs 2.56±1.50,t=-3.999,P 〈0.001)。结论 nCPAP能改善 OSAHS患者夜间多尿症状,其治疗压力越低患者夜尿次数越少。
Objective To investigate the effect of treatment with nasal continuous positive airway pressure(nCPAP)on night urination number in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Seventy-four patients diagnosed with moderate and severe OSAHS accompanying with nocturnal polyuria by polysomnography (PSG) monitoring and recording the number of nocturia were included,moderate group(n=14),severe group(n=31),extremely severe group(n=29).The number of nocturia and pressure were measured and recorded before and after nCPAP treatment.Results The number of nocturia was correlated with apnea-hypopnea index (AHI),the lowest nocturnal oxygen saturation (LSpO2) and ESS score (r =0.728,0.435,-0.293,P 〈0.05),and nocturia gradually increased with the AHI increased,after nCPAP treatment the number of nocturia reduced significantly(P 〈0.001).And nCPAP pressure was positively correlated with the number of nocturia (r=0.503,P 〈0.001),nCPAP pressure 〈9 cmH2 O nocturia were significantly less than nCPAP pressure≥9 cmH2 O group(1.30±1.10 vs 2.56±1.50,t=-3.999,P 〈0.001).Conclusions Treatment with nCPAP can improve symptoms on nocturnal polyuria in patients with OSAHS.And the lower the pressure,the less number of nocturia in patients with OSAHS.
出处
《国际呼吸杂志》
2016年第23期1796-1799,共4页
International Journal of Respiration
基金
广东省自然科学基金项目(2014A030313501)