阻塞性睡眠呼吸暂停综合征与肿瘤的关系研究进展

Association between obstructive sleep apnea syndrome and tumor

阻塞性睡眠呼吸暂停综合征（OSAS）是一种常见的严重危害人类健康的疾病，可致多个靶器官损害，目前有较多的证据表明 OSAS与肿瘤发生进展相关。流行病学研究表明 OSAS增加肿瘤的发病率与病死率，动物实验提示间歇性缺氧和睡眠片段化改变肿瘤生物学特点参与肿瘤进展。文章主要就 OSAS与肿瘤相关性及可能机制作一综述，希望为以后 OSAS研究提供新的视角。

Obstructive sleep apnea syndrome （OSAS） is a prevalent disorder with adverse effects on human health and multiple organ damage.Recently,emerging evidence indicate that the possible association between OSAS and cancer.The data from epidemiologic studies suggest that OSAS may contribute to increased cancer incidence and mortality.Experiments in animal models suggest that intermittent hypoxia and sleep fragmentation have effects on cancer biology and are likely contributing to tumor progression.In this review,we summarize the evidence supporting putative association between OSAS and cancer,and further explore mechanisms that may account for this association.The possible relationship between OSAS and cancer may provide new insight for further research.