斑秃患者甲状腺激素水平及甲状腺自身抗体的测定及分析

Detection and analysis of thyroxin and thyroid autoantibody levels in patients with alopecia areata

目的 :检测及分析斑秃(AA)患者甲状腺激素及自身抗体水平。方法 :采用化学发光免疫法检测111例斑秃患者(AA组)和85例正常人(正常对照组)血清中促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺球蛋白抗体(TGAb)及甲状腺过氧化物酶抗体(TPOAb)水平,并分别比较各组间甲状腺抗体的阳性率。结果:与正常对照组比较,AA组TSH水平降低,而FT3和FT4水平升高,但差异均无统计学意义(P均>0.05)。AA组TGAb阳性率与正常对照组相比,差异无统计学意义(P>0.05),但TPOAb阳性率较正常对照组明显升高,差异有统计学意义(P<0.05)。轻型及重型AA组间,复发性与非复发性AA组间TGAb及TPOAb阳性率比较,差异均无统计学意义(P均>0.05)。女性AA患者TPOAb阳性率高于男性AA患者(P<0.05)。结论 :AA患者TPOAb阳性率明显升高,且女性患者阳性率明显高于男性患者。

Objective： To detect the levels of thyroxin and thyroid autoantibodies in patients with alopecia areata（AA）. Methods： Chemiluminescence immunoassay was used to measure the levels of free triiodothyronin（FT3）, free thyronxine（FT4）, thyrotrophin（TSH）, thyroglobulin antibody（TGAb） and thyroperoxidase antibody（TPOAb） in 111 patients with AA and 85 healthy controls. The positive rates of thyroid antibodies were compared between AA and normal controls. Results： In comparison with normal controls, the levels of serum FT3 and FT4 were higher while the levels of TSH were lower in patients with AA, but no significant differences for either of them. TGAb positive rate was no significant differences between AA group and normal con- trols. In contrast, positive rate of TPOAb in patients with AA was significantly higher than that in normal controls（P〈0.05）. The positive rates of neither TGAb nor TPOAb differed significantly between the mild and severe AA group, or between the recurrent and non-recurrent AA group. The positive rate of TPOAb was higher in female patients than in male patients（P〈0.05）. Conclusion： The positive rate of TPOAb is significantly higher in patients with AA, and higher in female patients than in male patients.