微生物辅因子平衡的代谢调控

Manipulation of cofactor balance in microorganisms

辅因子平衡对于酶制剂、药品和化学品的生产具有重要的作用。为了满足工业化生产的需求,维持辅因子长期有效的平衡是实现代谢流高效化导向目标代谢产物的必要手段。本文在总结辅因子生理功能的基础上,从生化工程和代谢工程两方面分析归纳了辅因子的代谢调控策略,并展望了辅因子进一步精深调控的发展方向。

Cofactor balance plays an important role in producing enzymes, pharmaceuticals and chemicals. To meet the demand of industrial production, microbes should maintain a maximal carbon flux towards target metabolites without fluctuations in cofactor. We reviewed the physiological function of cofactor and discussed detailed strategies to manipulate cofactor balance through biochemical engineering and metabolic engineering. Furthermore, we indicated future research needs to further regulate cofactor balance.