鼻用纤维素粉末治疗变应性鼻炎的临床疗效研究

Clinical ettects assessment of nasal cellulose powder on allergic rhinitis

目的:探讨鼻用纤维素粉末治疗变应性鼻炎的临床疗效。方法:将50例变应性鼻炎患者随机分成实验组和对照组,每组各25例(最终分别完成24例及25例)。实验组鼻腔局部使用鼻用纤维性粉末喷鼻,对照组使用生理性海水喷鼻,于治疗3个月后评价患者鼻气道阻力、鼻部症状评分、鼻结膜炎生存质量量表(RQLQ)、嗅觉功能、鼻黏膜纤毛清除功能及不良反应。结果:2组患者均未见明显不良反应。实验组治疗后鼻阻力、鼻部症状评分及RQLQ评分(眼部症状除外)均较治疗前显著改善,其鼻部症状中的鼻痒、流涕、喷嚏症状及RQLQ中的睡眠、非鼻症状、鼻部症状、情感改善情况显著优于对照组,差异有统计学意义(P<0.05);而2组患者治疗后嗅觉功能及鼻黏膜纤毛清除功能均未见明显改善(P>0.05)。结论:鼻用纤维素粉末使用安全,可显著改善变应性鼻炎患者的主观症状,提高其生活质量。

Objective：To evaluate the role of nasal cellulose powder locally applied in allergic rhinitis patients.Method：Fifty patients with allergic rhinitis were divided randomly into two groups：the study group and the control group.The study group were treated with nasal cellulose powder while the control group were treated with physiological sea water.Objective and subjective examinations（nasal airway resistance,nasal syndrome score,rhinoconjunctivitis qualityof life questionnaire and olfactory function,nasal mucus cilia clearance）were performed before and 3months after treatment.Result：After treatment,partial parameters in nasal syndrome store（nasal itching,nasal discharge,sneezing and total store）and rhinoconjunctivitis qualityof life questionnaire（sleep,nasal symptom,non-hay-fever symptom,emotional function and total score）in the study group were significantly improved than those in the control group（P〈0.05）.However,no significant difference was found in olfactory function,Nasal airway resistance,nasal mucus cilia clearance and the eye symptom in rhinoconjunctivitis qualityof life questionnaire between the two groups after treatment（P〉0.05）.No adverse reaction was found in both groups.Conclusion：Nasal cellulose powder can help alleviate clinical symptoms and improve the quality of life in allergic rhinitis patients with no significant side effect.