安肠汤联合美沙拉嗪治疗溃疡性结肠炎的临床观察

Clinical Observation on Anchang Decoction combined with Mesalamine in the Treatment of Ulcerative Colitis

目的探讨安肠汤直肠滴入联合美沙拉嗪治疗溃疡性结肠炎的临床疗效。方法将纳入标准的溃疡性结肠炎患者90例,采用随机数字表法分为治疗组、对照1组和对照2组,每组30例。对照1组予美沙拉嗪口服及桂林西瓜霜直肠滴入治疗,对照2组予美沙拉嗪口服及康复新液直肠滴入治疗,治疗组予安肠汤直肠滴入联合美沙拉嗪治疗。结果治疗组与对照组临床疗效比较(P<0.05),治疗组能明显改善患者腹痛、腹泻、里急后重和黏液脓血便等症状;治疗组与对照1组结肠镜下黏膜表现比较(P<0.05),治疗组能有效缓解结肠黏膜充血水肿、黏膜溃疡、黏膜糜烂等症状;治疗组与对照2组结肠黏膜比较差异无明显意义。结论安肠汤直肠滴入联合美沙拉嗪治疗溃疡性结肠炎临床疗效显著,临床上值得进一步推广应用。

Objective To discuss the clinical curative effect of Anchang decoction rectum drip combined with mesalamine in the treatment of ulcerative colitis. Methods 90 patients with ulcerative colitis included in the standard were divided into treatment group,control group A and control group B by random number table method,with 30 cases in each group. The control group was given oral mesalamine and guilin watermelon frost rectum drip. The control group B was given oral mesalamine and Fukangxin liquid rectum drip. The treatment group was given Anchang decoction rectum drip combined with mesalamine. Results The treatment group was compared with control group on the clinical curative effect（ P 〈0. 05）,and the treatment group can significantly improve abdominal pain,diarrhea,tenesmus and mucous symptom such as purulent blood. The treatment group was compared with control group A on colonoscopy mucous membrane performance（ P〈 0. 05）,and the treatment group can effectively relieve the colonic mucosa congestion symptoms such as edema,mucosal ulcers,mucosal erosion. The treatment group was compared with control group B on colonic mucosa,and the difference had no significance.Conclusion Anchang decoction rectum drip combined with mesalamine in the treatment of ulcerative colitis has significantly clinical curative effect,and is worthy of further clinical application.