血管内皮生长因子家族及其受体与肿瘤血管新生

Vascular Endothelial Growth Factor Family and Tumor Angiogenesis

血管新生在肿瘤的生长及转移过程中发挥着极为重要的作用,而血管内皮生长因子(VEGF)是肿瘤血管新生过程中重要的促进因子,其能够与血管内皮细胞上相应的受体结合刺激内皮细胞增殖、迁移,进而促进肿瘤血管新生。阻断VEGF与其相应的受体结合可以抑制肿瘤的生长。目前研究以VEGF及其受体为靶点的血管新生抑制剂如单克隆抗体、多靶点酪氨酸激酶抑制剂以及小干扰RNA等给肿瘤的治疗带来了新希望。

Angiogenesis plays an important role in tumor growth and metastasis, and vascular endothelial growth factor （VEGF） is an important promoting factor in the process of tumor angiogenesis, which can bind to corresponding receptors on vascular endothelial cells, stimulating endothelial cell proliferation, migration, and promoting tumor angiogenesis. Blocking VEGF binding to its corresponding receptor can inhibit tumor growth. Nowadays, angiogenesis inhibitors such as monoclonal antibody, multi-target tyrosine kinase inhibitor and small interfering RNA targeting VEGF and its receptor have brought new hopes tot the treatment of tumor.