加味三香汤对功能性腹胀患者胃肠传输功能的影响

Effects of Modified Sanxiang Decoction on Gastrointestinal Transmission Function of Patients with Functional Bloating

目的观察加味三香汤对功能性腹胀(FB)患者中医症状改善及胃肠传输功能的影响。方法将60例FB患者随机分为中药组40例和对照组20例。中药组予加味三香汤,对照组予安慰剂颗粒,每次1袋,每日2次,冲服。2组均治疗21 d。观察2组治疗前后中医症状积分、48 h胃肠通过率(48 h GITT),并记录不良反应情况。结果 2组治疗后中医症状积分与治疗前比较,差异有统计学意义(P<0.05)。治疗后,中药组腹胀、嗳气、纳差积分及中医症状总分均低于对照组,差异有统计学意义(P=0.000、0.000、0.010、0.003)。中药组总有效率为82%(33/40),对照组为30%(6/20),中药组疗效优于对照组(P<0.05)。共30例完成胃肠传输试验,其中48 h GITT延缓者占54%(16/30)。中药组48 h GITT较对照组改善更明显,2组比较差异有统计学意义(P=0.002)。2组均未见明显不良反应。结论 FB患者多存在肠动力异常情况,加味三香汤能够改善FB中医症状,促进肠动力,改善肠道传输功能。

Objective To study the effects of modified Sanxiang Decoction on gastrointestinal transmission function of patients with functional bloating（FB）. Methods Sixty cases of FB patients were randomly divided into treatment group（40 cases） and control group（20 cases）. Treatment group was given modified Sanxiang Decoction, while control group was given placebo granules, one bag each time. Twice a day, taking it after mixing it with water. Gastrointestinal symptoms, 48 h GITT, and adverse reactions were recorded. Results There was statistical significance in TCM symptom scores between before and after treatment in the two groups（P0.05）. After treatment, the total score of abdominal distension, belching, anorexia and TCM symptoms of the treatment group were lower than the control group, with statistical significance（P=0.000, 0.000, 0.010, 0.003）. The total effective rate was 82%（33/40） in the treatment group, 30%（6/20） in thecontrol group; the treatment group was better than the control group（P0.05）. A total of 30 patients completed gastrointestinal transit test, of which delayed 48 h GITT pass rate accounted for 54%（16/30）. Compared with the control group, the 48 h GITT of the treatment group was more obviously improved than that of the control group with statistical significance（P=0.002）. There were no significant adverse reactions in both groups. Conclusion Most of FB patients have the problem of abnormal intestinal motility. Modified Sanxiang Decoction can improve the symptoms of patients with FB, promote gastrointestinal motility, and improve intestinal transmission function.