卤代金刚烷衍生物的合成研究进展

Review on Synthesis of Halogenated Adamantane Derivatives

卤代金刚烷衍生物作为重要的有机中间体,在医药、高分子、含能材料等领域中有着广泛的应用。综述了卤代金刚烷衍生物的合成方法及应用前景,主要包括1-氟金刚烷、1,3,5,7-四氟金刚烷、1-氯金刚烷、1,3,5,7-四氯金刚烷、3-氯金刚烷甲酸、3,5-二氯金刚烷甲酸、八氯代金刚烷甲酸、1-溴金刚烷、1,3-二溴金刚烷、1,3,5,7-四溴金刚烷、1-碘金刚烷、1,3,5,7-四碘金刚烷等。认为多卤代金刚烷衍生物的分离提纯工艺、金刚烷结构上引入8个以上卤原子的工艺路线及寻找卤代金刚烷衍生物合成中需要的绿色试剂和催化剂等是今后的研究重点。

Halogenated adamantine derivatives are widely applied in the field of medicinal chemist, polymer and energetic materials as organic chemical intermediates. This review is intended to provide the synthetic methods of halogenated adamantine compounds, including 1-fluoroadamantane, 1-chloroadamantane, 1,3,5,7-tetrachloroadamantane, 3-chloroadamantane-1-carboxylic acid, 3,5-dichloroadamantane-1-carboxylic acid, octachloroadamantane-1-carboxylic acid, 1-bromoadamantane, 1,3-dibromo- adamantane, 1,3,5,7-tetrabromoadamantane, 1 -iodoadamantane and 1 , 3,5,7-tetraiodoadamantane. It is worthy of further research, which includes the purification and separation process of polyhaloadamantane, new synthesis routes of halogenated adamantine with more than eight halogen atomes and new green reagents and catalysts.