摘要
作为一种具有特殊网络结构和功能的天然高分子材料,胶原基水凝胶已在医用敷料、药物载体、组织工程支架等生物医学领域得到了广泛应用。对近几年胶原基水凝胶的研究应用现状进行了全面综述,从胶原的结构与性能入手,着重对胶原基水凝胶的制备、结构性能表征及其在生物医学中的应用进行了阐述,同时对制备过程条件的控制对水凝胶结构性能的影响进行了重点讨论,对胶原基水凝胶的未来前景和发展重点进行了展望,有望为将来有关胶原基水凝胶的研究和应用提供数据参考。
Collagen based hydrogels have been used successfully as three-dimensional substrates and have shown promise for biomedical engineering. This article comprehensively reviews the research work carried out in the last few years on collagen based hydrogels with particular emphasis on preparation, characterization and biomedical applications. A significant body of this work has been devoted to state the relationship between the preparation conditions and the structure and performance of products. Ultimately, this review can serve as a resource for selection of fabrication parameters and hydrogels characterization methodologies.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2017年第1期1038-1046,共9页
Journal of Functional Materials
基金
国家自然科学基金青年科学基金资助项目(21506070)
湖北省自然科学基金青年科学基金资助项目(2015CFB391)
华中农业大学自主科技创新基金资助项目(2662015QC014)
关键词
胶原
水凝胶
三股螺旋
自组装
交联
collagen
hydrogel
triple-helix
self-assembly
cross-linking
