脉冲振荡法及常规通气法在检测哮喘患儿肺功能的价值研究

The study of applications of impulse oscillation system and routine pulmonary ventilation method for detecting pulmonary function of Children with asthma

目的:分析常规通气法及脉冲振荡法在检测哮喘患儿肺功能的临床应用价值。方法:选取103例急性期哮喘患儿,收集患儿两种检测方法的7个肺功能指标:即第1 s用力呼气容积(FEV1)、呼气峰流速(PEF)、最大呼气中段流量(MMEF)和呼吸总阻抗(Zrs)、总气道阻力(R5)、中心气道阻力(R20)以及周边弹性阻力(X5),并对研究数据进行统计分析。结果:FEV1、PEF和MMEF与Zrs、R5、R20存在负相关关系(r=-0.825,r=-0.732,r=-0.846,r=-0.722,r=-0.637,r=-0.797,r=-0.785,r=-0.691,r=-0.847;P<0.05),与X5存在正相关关系(r=0.729,r=0.524,r=0.783;P<0.05),随着哮喘病情严重程度的增加,Zrs、R5及R20增加,而X5减小。结论:肺功能检查能了解哮喘患儿肺功能受损的程度,对儿童哮喘的诊断、病情和治疗效果的判断具有重要价值,而脉冲振荡法和常规通气法的检测可提高对儿童哮喘的临床应用价值。

Objective： To analyze the value of applications of impulse oscillation system and routine pulmonary ventilation method for detecting lung function of children withasthma. Methods： 103 asthmatic children in acute episode were selected, and 7 pulmonary function indexes using two methods mentioned were statistical analyzed, which consisted of FEV1（the forced expiratory volume in one second）, PEF（peak expiratory flow）, MMEF（maximal mid expiratory flow） and Zrs（respiratory system impedance）, R5（total airway resistance）, R20（central airway resistance）, X5（peripheral elastic resistance）. Results： There was negative correlation between FEV1, PEF, MMEF and Zrs, R5, R20（r=-0.825, r=-0.732, r=-0.846, r=-0.722,r=-0.637, r=-0.797, r=-0.785, r=-0.691, r=-0.847; P〈0.05）. And there was a positive correlation between FEV1, PEF, MMEF and X5（r=0.729, r=0.524, r=0.783; P〈0.05）. That was, with the degree of asthma increasing, the Zrs, R5 and R20 increased while the x5 decreased. Conclusion： Pulmonary function tests can be used to judge the severity of Pulmonary function in children with asthma, so these tests have enormous value in diagnosis and treatment of childhood asthma. Combined application of impulse oscillation system and conventional pulmonary ventilation method has important clinical values in detecting pulmonary function of Children with asthma.