腰椎原发性非特异性感染的危险因素分析

Analysis of risk factors of primary non-specific infection in lumbar spine

目的探讨腰椎原发性非特异性感染的危险因素。方法回顾性分析自2012-06—2015-07经影像学、实验室检查或结合病理检查确诊的24例腰椎原发性非特异性感染,分析感染的危险因素。结果本组腰椎原发性非特异性感染24例,占腰椎疾病的1.75%,占脊柱感染的4.25%。血培养结果或者病灶清除术时病理结果 :金黄色葡萄球菌11例(45.8%),大肠埃希菌4例(16.7%),肺炎链球菌1例(4.2%),真菌2例(8.3%),6例(25.0%)未培养出细菌。腰椎原发性非特异性感染的危险因素:4例全身多发性感染,2例有接触感染源(猫、狗),3例长期使用激素或免疫抑制剂,1例长期使用抗生素,1例静脉药物成瘾,4例合并基础疾病,10例年龄≥60岁,16例文化程度在小学以下,男女比例为3∶1。结论全身多发性感染、接触感染源、长期使用激素、免疫抑制剂、滥用抗生素、男性、高龄、合并基础疾病等因素与腰椎原发性非特异性感染有关。

Objective To investigate the risk factors of primary non-specific infection in lumbar spine. Methods Twenty- four cases of primary non-specific infection in lumbar spine confirmed by imaging, laboratory examination or pathology from June 2012 to July 2015 were retrospectively reviewed and the risk factors were analyzed. Results This study contained 24 cases of primary non-specific infection in lumbar spine, which was 1.75% of lumbar diseases and 4.25% of spinal infection respectively. The results of blood culture or pathological examination were as follows： 11 cases （45.8%） of Staphylococcus aureus, 4 cases（16.7%） of Eschefichia colt, 1 case of Streptococcus pneumonia（4.2%）, 2 cases of fungus（8.3%）, and 6 cases （25.0%） negative results. The risk factors of infection included 4 cases of multiple systemic infection, 2 cases of contact infection （cats, dogs）, 3 cases of long-term use of hormones or immunosuppressive agents, 1 case of long-term use of antibiotics, 1 case of intravenous drug addiction, 4 cases of combined underlying diseases, 10 cases of age ≥ 60 years old, 16 cases of under primary school education with 3：l of male/female ratio. Conclusion The whole body of muhiple infections, contact infection, long-term use of hormones or immunosuppressive agents, abuse of antibiotics, men, age and combined underlying diseases are associated with primary non-specific infection of lumbar spine.