舒肝解郁胶囊联合美沙拉秦治疗伴焦虑抑郁状态溃疡性结肠炎效果观察

Observation of effect of Shuganjieyu capsule on ulcerative colitis with anxiety and depression

目的探讨舒肝解郁胶囊联合美沙拉秦治疗伴焦虑抑郁状态溃疡性结肠炎的效果。方法选择伴有焦虑抑郁状态的初发型轻度或中度活动期溃疡性结肠炎患者60例,按照随机数字表法随机分为对照组和观察组,每组30例。对照组予美沙拉秦(1 g/次,4次/d)口服,观察组在此基础上联合给予舒肝解郁胶囊(2粒/次,2次/d)口服,疗程均为8周。治疗前及治疗8周后,观察临床症状、肠镜下表现,改良Mayo评分、医院焦虑抑郁自评量表(HADS)评分、炎症性肠病生存质量问卷(IBDQ)评分的变化,记录2组不良反应发生情况。结果治疗8周后,观察组Mayo评分显著低于对照组(P<0.05),临床有效率显著高于对照组(P<0.05),HADS评分中焦虑和抑郁积分均显著低于对照组(P<0.05),IBDQ评分显著高于对照组(P<0.05),2组不良反应发生率比较差异未见统计学意义。结论舒肝解郁胶囊可有效缓解溃疡性结肠炎患者焦虑抑郁状态,改善生活质量,进而有助于减轻疾病活动程度并提高疗效。

Objective It is to investigate the therapeutic effect of Shuganjieyu capsule combined with mesalazine on ulcerative colitis（ UC） with anxiety and depression. Methods A total of sixty mild to moderately active UC patients with anxiety and depression were randomly divided into control group and observation group by random number method,30 cases in each group.The patients in control group were treated with mesalazine（ 1 g / time,4 times / d,oral）,while the patients in observation group were treated with Shuganjieyu capsule（ 2 pills / time,2 times / d,oral） on the basis of treatment with mesalazine. The course of treatment in both groups was 8 weeks. Before treatment and 8 weeks after treatment,the clinical symptoms and manifestation under endoscopic examination were observed. The severity of the disease activity of UC and the clinical curative effect were evaluated by the modified Mayo score. The anxiety and depression of the patients were assessed by the hospital anxiety and depression self rating scale（ HADS）. The quality of life of these patients was evaluated by inflammatory bowel disease QOL questionnaire（ IBDQ）. The adverse reactions occurred in both group were recorded. Results After 8 weeks of treatment,the observe group had a significantly lower Mayo score compared with the control group（ P〈0. 05）,with a significantly higher clinical efficacy（ P〈0. 05）,a significantly lower HADS scores（ P〈0. 05）,and a significantly higher IBDQ score（ P〈0. 05）. There was no significant difference in incidence of adverse reactions between the two groups. Conclusion Shuganjieyu capsule can effectively alleviate the anxiety and depression of ulcerative colitis patients,and improve the quality of life,thereby helping to relieving the extent of disease activity and improve the curative effect.