茵栀黄颗粒作为肝病辅助用药作用机制的网络药理学研究

Network Pharmacology Study of Liver Disease Adjuvant Characteristics of Yinzhihuang Granules Based on Correlation Mechanism

目的:通过网络药理学方法,探讨茵栀黄颗粒作为肝病辅助用药的辅助治疗机制。方法:通过TDT数据库和Pharm Mapper Server数据库筛选出茵栀黄颗粒的作用靶点;通过在线人类孟德尔遗传数据库筛选出肝炎的疾病作用靶点,通过蛋白质交互网络数据库综合分析茵栀黄颗粒治疗肝炎的"化学成分-靶点-疾病"交互网络,利用Cytoscapy 3.0软件分析以上交互网络中各节点的拓扑参数,得出茵栀黄颗粒抗肝炎的作用机制。结果:网络药理学分析结果表明,茵栀黄颗粒主要通过干预机体炎症反应、保护肝细胞而辅助治疗肝炎。结论:作为肝病辅助用药的茵栀黄颗粒能干预机体炎症反应、保护肝细胞,可辅助治疗肝炎,适用于肝病伴有炎症反应和肝细胞受损患者。该研究对临床肝病的辅助治疗具有指导意义。

OBJECTIVE： To probe into the mechanism of therapeutic action of Yinzhihuang granules as liver disease adjuvant through network pharmacology. METHODS： To select the targets of Yinzhihuang granules through TDT database and Pharm Mapper Server database; and the targets of hepatitis through OMIM database. The targets of drug and disease were analyzed with PPI database which could obtain an interactive network of ＂compound-target-disease ＂. Topology parameter value of the dots of the ＂compound-target-disease ＂was analyzed with Cytoscapy 3. 0,so as to obtain the mechanism of therapeutic action of Yinzhihuang granules. RESULTS： According to the analysis of network pharmacology,Yinzhihuang granules in treatment of hepatitis mainly though intervening the inflammatory reaction and protecting hepatocytes. CONCLUTIONS： As liver disease adjuvant,Yinzhihuang granules can be used in treatment of hepatitis though intervening the inflammatory reaction and protecting hepatocytes. It can be applied for the patients with inflammation and hepatocellular injury. This study can prove meaningful guidance for using medicines of liver disease for clinical.